![]() Title: The role of microRNA activity in regulating synaptic dysfunction in Alzheimer’s disease Relationship between synaptic dysfunction and degeneration in a rodent model of dementia Title: A multiphoton imaging facility for in vitro and in vivo studies of CNS function and disease. Title: Contribution to the purchase of a Ti-Sapphire laser to enable establishment of multiphoton fluorescence imaging facility. Title: Improving Neurotransmission through the Brain’s Memory Centres: A Pharmacogenetic Approach to Treating Dementia. Title: Functional consequences of impaired gamma frequency oscillations in mouse models of dementia. Title: Regulatory genomic variation in rodent models of amyloid and tau neuropathology Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia 2018 National Centre for the Replacement Refinement.More recently they have been using recording techniques that allow them to record network activity from multiple brain regions simultaneously, to explore the impact of cellular level changes on larger scale network interactions. ![]() They use these approaches to explore the synaptic and intrinsic properties of these neurons. They make whole-cell recordings from neurons in brain areas known to be affected in these diseases, such as the hippocampus, entorhinal cortex and prefrontal cortex. Furthermore, there is increasing evidence that more subtle changes to synaptic circuits may underlie the cognitive deficits that occur earlier on in the disease, prior to detectable neuronal loss.ĭr Brown and his colleagues aim to characterize these changes in neuronal networks at multiple levels of complexity, using mouse models of dementia and schizophrenia. For example, in late-stage AD, there is substantial neurodegeneration which alters the integrity of the surviving network. Cognitive dysfunction in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia arise from changes to neuronal networks. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |